Login
Register

Home

About Us

Diagnoses

Treatments

Classes

Resources

Media

Testimonials

Blog

Account

Blog
Register
Woman crouching next to bed holding on to stomach

How do histamines effect Interstitial Cystitis?

Newly published research by Grundy et al. (2019) shows a more direct connection between histamines and interstitial cystitis (Painful Bladder Syndrome or Bladder Pain Syndrome).

In this study, to be published in the upcoming February 2021 issue of The American Journal of Physiology: Renal Physiology, Grundy et al. show correlation that histamines in the body lead to changes in the sensory nerves of the bladder, particularly hypersensitivity during bladder distension, or when the bladder is filling or full.

The study determined that certain sensory nerves in the bladder can become more sensitive when histamines are present. This activation occurs in the bladder membrane, the detrusor muscles, as well as the afferent nerves of the bladder.

The study also suggests that histamines can increase the activation of certain sensory nerve cell bodies in the central nervous system, which may affect the sensation of fullness of those with IC/BPS.

In a previous study by Shan et al. (2019) also showed the important role of histamines in IC/BPS. In that study, bladder tissues were collected from 69 BPS/IC patients and 10 control female patients. The study found that 4 histamine receptors were more reactive in the patients with IC/BPS.

These findings will hopefully help guide treatment for this dysfunction which greatly affects quality of life for many of our clients.

What is Painful Bladder Syndrome / Interstitial Cystitis?

Interstitial Cystitis (AKA Painful bladder syndrome or Bladder pain syndrome) is a complex bladder dysfunction characteristized by the following symptoms:

  • More than 6 months of urinary bladder pain or discomfort
  • Accompanied by urinary symptom such as:
    • Persistent urge to void
    • Urinary urge with pressure
    • Burning and aching pain
    • Increased frequency of urination (more than 8x daily)
  • IC can contribute to chronic pelvic pain and poor quality of life, and may have associated symmptoms like:
  • Low back pain
  • Pain during sex or pain after sex

Musculoskeletal Dysfunction and IC Symptoms

Recent research supports that musculoskeletal dysfunction, specifically in the pelvic floor, can refer symptoms to the bladder and urethra. A full intake examination with a trained pelvic floor physical therapist can help determine if this is the case for you.

Contact us with any questions you may have about your Painful Bladder Syndrome or Interstitial Cystitis diagnosis. We have a number of treatment options available!

 

Resources

Shan H, Zhang EW, Zhang P, et al. Differential expression of histamine receptors in the bladder wall tissues of patients with bladder pain syndrome/interstitial cystitis - significance in the responsiveness to antihistamine treatment and disease symptoms. BMC Urol. 2019;19(1):115. Published 2019 Nov 12. doi:10.1186/s12894-019-0548-3

Jones BM, Tykocki NR. New direct evidence that histamine augments bladder sensory outflow during filling is nothing to sneeze at. Am J Physiol Renal Physiol. 2020 Feb 1;318(2):F455-F456. doi: 10.1152/ajprenal.00581.2019. Epub 2020 Jan 6. PMID: 31904288; PMCID: PMC7052655.

Grundy, L., Caldwell, A., Garcia Caraballo, S., Erickson, A., Schober, G., Castro, J., … Brierley, S. M. (2019). Histamine induces peripheral and central hypersensitivity to bladder distension via the histamine H1 receptor and TRPV1. American Journal of Physiology-Renal Physiology. doi:10.1152/ajprenal.00435.2019

Star InactiveStar InactiveStar InactiveStar InactiveStar Inactive
 

What They Say About Us

  • Testimonials

    • Testimonial by S.H., age 24

      I just wanted to thank you for everything you've done for me for the past 19 months. I literally could not have reached my goals without you and your practice. You gave me the courage to keep moving forth with my treatment no matter how afraid and anxious I was. You were always there to answer questions and made this whole process so much easier than I expected it to be. It's because of you that my marriage is on the right track, that I can get pregnant and that this part of my life is finally...

      Read more Testimonial by S.H., age 24

  • Testimonials

    • Testimonial by Y.L. (mom of 2)

      After having my second baby via C-section I searched for months to try to find help for my lower back pain and separated abdominal muscles. I finally came across Heather Jeffcoat via a mommy blog. I reached out to her via email and set my first appointment. My first appointment went amazing … she listened to what my symptoms, check my separation and explained to me in detail what the next steps would be. Not only did my abdominal separation go from 3 to about 1 -1/2 but my back has pain has...

      Read more Testimonial by Y.L. (mom of 2)

Subscribe To Our Newsletter

captcha